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KMID : 0895820200300030103
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Journal of Oriental Rehabilitation Medicine
2020 Volume.30 No. 3 p.103 ~ p.116
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The Effect of Herbal Medicine on Rheumatoid Arthritis Animal Model: A systematic Review of Animal Experiment Studies Published in Korea and Overseas
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Oh Seung-Joon
Ha Hyung-Ju
Gu Ji-Hyang
Park Yang-Chun
Oh Min-Seok
Jung In-Chul
Lee Eun-Jung
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Abstract
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Objectives : This study was designed to review the effect of herbal medicine on animal model with rheumatoid arthritis.
Methods : We reviewed studies published both in Korea and overseas, all published after 2008. We investigated 8 databases, 6 Korean databases and 2 of abroad. Searching was conducted through flowchart and 24 studies met our guideline. Datas were extrated and organized as animal model characteristics, experimental period, study design, herbal medicine used as intervention and rheumatoid arthritis indicator.
Results : 336 articles were primarily selected. After screening, 24 articles were left in the end. All 24 studies showed that the herbal medicine used in the animal experiment was effective on treating rheumatoid arthris, proven by macroscopic, histological, hematological and osteological indicators.
Conclusions : The result showed that herbal medicine is effective in treating rheumatoid arthritis through various pathways. However, study design and intervention were all different from each other and we could not specify the certain compound, material or substance of efficacy. Further study should be conducted to figure out the effectiveness of herbal medicine on rheumatoid arthritis.
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KEYWORD
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Rheumatoid arthritis, Korean traditional medicine, Chinese herbal drugs, Systematic review, Animal experimentation
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